Abstract
The influence of physical exercise on the tumortoxicity of peritoneal murine macrophages
(PMM) was investigated. The tumortoxic activity was discriminated into cytostatic
and cytolytic effects. Cytostatic activity of PMM on tumor cells in vitro was studied
using the proliferation assay of S-180 sarcoma cells. Cytolytic activity was monitored
using the method of the slow form of antibody-dependent cellular cytotoxicity (ADCC)
on SW 707 tumor cells. After a single exhaustive running session an increased cytostatic
activity of PMM was observed as compared to PMM of sedentary animals. In PMM mediated
ADCC no difference was detected between trained and untrained animals. It is concluded
that physical exercise is a complex stimulus for macrophages that, at least in parts,
triggers their cytotoxic activity against tumor cells.
Key words
Macrophages - cytostasis - ADCC - training
